Comparative Effectiveness Research / PCORI

The analysis of the relative effectiveness of different medical treatments. The Patient-Centered Outcomes Research Institute (PCORI) is a government-sponsored organization set up to fund this analysis.  

International Comparison of Frameworks for Valuing Drugs

Mar. 1, 2017

“Pay more for drugs that do more.” Although few would argue with the concept of paying for value, the mechanism for doing so has thus far eluded our multi-payer, market-based system. The Gant Precision Cancer Medicine Consortium at the University of Pennsylvania looked past US borders to learn about mechanisms in other countries, in its quest to recommend sustainable frameworks for valuing precision cancer drugs.

Focused Cardiac Ultrasound in Place of Repeat Echocardiography: Reliability and Cost Implications

Oct. 1, 2015

Vinay Kini, Nidhi Mehta, Jeremy Mazurek, Victor Rerrari, Andrew Epstein, Peter Groeneveld, James Kirkpatrick

In the Journal of the American Society of Echocardiography, Vinay Kini and colleagues, including Andrew Epstein and Peter Groeneveld, assess the reliability and cost-effectiveness of using expert focused cardiac ultrasound (eFCU) in place of repeat transthoracic echocardiography (TTE). Rates of repeat TTE (two or more performed within 30 days) are high and can substantially increase the cost of providing cardiovascular care. The authors enrolled patients with prior TTE within 30 days who were ordered for another TTE. Participants underwent eFCU in addition to TTE and the study...

Comparison of HIV Outcomes for Patients Linked at Hospital Versus Community-Based Clinics

Mar. 1, 2015

Asher J. Schranz, Kathleen A. Brady, Florence Momplaisir, Joshua P. Metlay, Alisa J. Stephens-Shields, Baligh R. Yehia

In AIDS Patient Care and STDs, Asher Schranz (New York University) and colleagues, including Baligh Yehia, compare HIV treatment outcomes for patients in hospital-based clinics versus those accessing care in a community clinic. The authors studied 2008-2011 data on HIV-infected adults in Philadelphia, assessing treatment outcomes in terms of retention in care, use of antiretroviral therapy, and viral suppression. Controlling for differences in patient and clinic characteristics, the authors find no difference in treatment outcomes between patients in hospital-based and community-based...

Presentation of Prescription and Nonprescription Opioid Overdoses to U.S. Emergency Departments

Feb. 26, 2015

Michael A. Yokell, M. Kit Delgado, Nicholas D. Zaller, N. Ewen Wang, Samuel K. McGowan, Traci Craig Green

In JAMA Internal Medicine, Kit Delgado and colleagues investigate characteristics of opioid overdose presentations to emergency departments. Opioid overdose is a leading cause of injury-related mortality in the United States. They analyze data from 2010 on 135,971 patients with opioid overdoses who were treated in emergency departments. The authors evaluate opioid type, patient characteristics, care utilization and clinical outcomes. They find that: two thirds of overdose cases involved prescription opioids, mortality was higher for overdoses with multiple opioids, most...