Dr. Audrain-McGovern is a Professor in the Department of Psychiatry and a member of the Cancer Center at the University of Pennsylvania. Her research spans epidemiology, behavioral pharmacology and clinical trials. Dr. Audrain-McGovern’s epidemiological research focuses on identifying and understanding the bio-behavioral determinants of adolescent smoking acquisition, the relationship between adolescent e-cigarette use and subsequent combustible cigarette smoking, and the pathways to the dual use of tobacco products. This research has used behavioral economic theory to conceptualize the initiation, escalation and persistence of tobacco use in adolescents and young adults. Dr. Audrain-McGovern's human laboratory research has focused on understanding (1) how substitute alternative reinforcers, such as physical activity, can compete with cigarette smoking to promote smoking cessation, and (2) how behavioral economic paradigms can be used to identify novel smoking cessation treatment targets for smokers with depression. Dr. Audrain-McGovern's clinical trial research involves using behavioral economic informed interventions to target multiple co-occurring behaviors. She is currently evaluating how targeting one underlying mechanism, reward deficits, can promote smoking cessation while minimizing post-cessation increases in food intake and subsequent weight gain. Dr. Audrain-McGovern has served as the Director of the Training and Career Development Core for three P50 center grants focused on nicotine and tobacco research as well as the Co-Director of the Training and Career Enhancement Core for two Tobacco Centers for Regulatory Science at UPENN. She has served as an Associate Editor for Nicotine & Tobacco Research and Tobacco Regulatory Science, a program chair for the Society for Research on Nicotine and Tobacco, and has served on numerous NIH study sections.