Ralph I. Horwitz, MD, MACP, Professor of Medicine and Director, Transformative Medicine Institute, Temple University and Harold H. Hines, Jr. Professor Emeritus of Medicine and Epidemiology at Yale University. Dr. Horwitz trained in internal medicine at institutions (Royal Victoria Hospital of McGill University and the Massachusetts General Hospital) where science and clinical medicine were connected effortlessly. These experiences as a resident stimulated a deep interest in clinical research training that he pursued as a fellow in the Robert Wood Johnson Clinical Scholars Program at Yale under the direction of Alvan R. Feinstein. He joined the Yale faculty in 1978 and remained there for 25 years as Co-Director of the Clinical Scholars Program and later as Chair of the Department of Medicine. Dr. Horwitz was Chair of Medicine at Stanford, Dean of Case Western Reserve Medical School and most recently Senior Vice President for Clinical Sciences at GlaxoSmithKline. Dr. Horwitz’ research interests are in the methods used to study the strategies of clinical care. He has published widely on methods for the etiology, diagnosis, prognosis and treatment of disease. He is an elected member of the National Academy of Medicine/Institute of Medicine; the American Society for Clinical Investigation; the American Epidemiological Society; and the Association of American Physicians (he was President in 2010). He was a member of the Advisory Committee to the NIH Director (under both Drs. Elias Zerhouni and Francis Collins). Dr. Horwitz served on the American Board of Internal Medicine and was Chairman in 2003. He co-chaired the IOM Clinical Effectiveness Research Innovation Collaborative. He is a Master of the American College of Physicians.