Penn Implementation Science Center (PISCE) @ LDI
Advancing the science of implementation and training the next generation of implementation researchers

PISCE working group at LDI


Photo: Hoag Levins
At a recent Penn Implementation Science Center (PISCE) works-in-progress meeting, Drexel University's Jonathan Purtle, DrPH, MPH, MSc, discusses the effort to find more effective ways for disseminating evidence about the health effects of toxic stress in children to policymakers.

As health and community settings grapple with resource-constrained conditions, the use of evidence-based strategies in routine practice will be critical to maximizing the value of care and improving health outcomes. Implementation science research plays a critical role in promoting uptake of these strategies. Penn is home to a rich network of implementation science expertise and activities across many fields in health care. Activities include grant-funded projects, an education program, an annual Implementation Science Institute, and an ongoing working group.

Applying Behavioral Insights to Mental Health Care 

Led by Drs. Rinad Beidas, David Mandell, and Kevin Volpp, the goal of ALACRITY (Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness) is to apply insights from behavioral economics and participatory design to advance the science and practice of implementing evidence-based practice for individuals with psychiatric disorders across the lifespan. It includes three exploratory projects and a methods core and represents a collaboration between the Center for Mental Health Policy and Services Research and the Center for Health Incentives and Behavioral Economics.

Improving Asthma Care for Kids

An interdisciplinary team at CHOP and Penn led by Dr. Tyra Bryant-Stephens is studying the effectiveness and implementation of patient-centered interventions designed to increase asthma control in pediatric populations across West Philadelphia.

De-implementing an Overused Practice

A team led by Dr. Christopher Bonafide is studying how to de-implement an overused practice. Their goal is to Eliminate Monitor Overuse (EMO: SpO2) in hospitalized infants who are successfully recovering from the common viral lung disease bronchiolitis.

Improving Patient Handoffs

Led by Dr. Meghan Lane-Fall, the Handoffs and Transition in Critical Care (HATRICC) project, seeks to use implementation science to improve handoffs of patients from the Operating Room (OR) to the Intensive Care Unit (ICU) at Penn Presbyterian and at the Hospital of the University of Pennsylvania.

Basser Center for BRCA Studies

The Basser Center for BRCA is currently involved with two implementation studies in the area of cancer genetics.

  • The first study, BRCA Founder Outreach Study (BFOR) assesses the effectiveness of a new model for genetic testing in the Ashkenazi Jewish population, incorporating a state-of-the-art online platform and a partnership with primary care providers. The BFOR study is a multi-site study taking place in Philadelphia, New York, Boston, and Los Angeles.
  • The Point of Care Study evaluates an alternative clinical cancer genetics delivery model among patients with advanced, metastatic pancreas or prostate cancer. The goal of this study is to provide efficient and effective clinical genetics care within the non-genetics care medical setting.

Implementation Science Working Group

  • Founded in 2011 to create a community around implementation science at Penn, the working group situates Penn as a leader in advancing the science of implementation and provides training opportunities for the next generation of implementation science researchers.
  • The working group supports development of research to guide the implementation of evidence-based interventions across a range of healthcare settings. Past activities include a conference and a speaker series. Bimonthly work in progress meetings focus on research proposals, ongoing projects, manuscripts and pilot grant funding.
  • To learn more about the working group, or attend a meeting, contact marxd@upenn.edu.

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Transforming Mental Health Delivery Through Behavioral Economics and Implementation Science: A Project Protocol, JMIR Research Protocols, In Press, Beidas, Volpp, Buttenheim, Marcus, Olfson, Pellecchia, Stewart, Williams, Becker-Haimes, Candon, Cidav, Fishman, Lieberman, Zentgraf, Mandell

A Cluster-Randomized Clinical Trial Testing the Effectiveness of the Addressing Tobacco through Organizational Change (ATTOC) Model for Improving the Treatment of Tobacco Use in Community Mental Healthcare: Preliminary Study Feasibility and Baseline Findings, Nicotine and Tobacco Research, In Press, Flitter, Lubitz, Ziedonis, Stevens, Leone, Mandell, Kimberly, Lopez, Beidas, Schnoll

Barriers and Facilitators for Emergency Department Initiation of Buprenorphine: A Physician Survey, American Journal of Emergency Medicine, February 2019, Lowenstein, Kilaru, Perrone, Hemmons, Abdel-Rahman, Meisel, Delgado

Stakeholder Perspectives on Implementing a Firearm Safety Intervention in Pediatric Primary Care as a Universal Suicide Prevention Strategy, JAMA Network Open, November 2018, Wolk, Van Pelt, Jager-Hyman, Ahmedani, Zeber, Fein, Brown, Gregor, Lieberman, Beidas

Understanding the Landscape of Behavioral Health Pre-service Training to Inform Evidence-Based Intervention Implementation, Psychiatric Services, October 2018, Becker-Haimes, Okamura, Baldwin, Wahesh, Schmidt, Beidas

Implementation Science in Perioperative Care, Anesthesiol Clin., March 2018, Lane-Fall, Cobb, Cené, Beidas

Changing Antibiotic Prescribing in a Primary Care Network: The Role of Readiness to Change and Group Dynamics in Success, American Journal of Medical Quality, July 2017, Elango, Szymczak, Bennett, Beidas, Werner

Reducing Overuse of Cervical Cancer Screening: A Systematic Review, Prev Med., August 2018, Alber, Brewer, Melvin, Yackle, Smith, Ko, Crawford, Glanz

Use of Evidence-Based Interventions and Implementation Strategies to Increase Colorectal Cancer Screening in Federally Qualified Health Centers, Journal of Community Health, May 2018, Adams, Rohweder, Leeman, Friedman, Gizlice, Vanderpool, Askelson, Best, Flocke, Glanz, Ko, Kegler