In JAMA Oncology, Mina Sedrak and colleagues, including Raina Merchant and Marilyn Schapira, analyzed Twitter content to describe communication about lung cancer clinical trials and to examine where links embedded in tweets about therapeutic trials are leading the public. In an analysis of a random 10% of tweets identified, they find that Twitter is commonly used for support and prevention. Although some tweets refer to clinical trials, virtually none are used for recruitment or provide links to enrollment websites. Twitter’s potential to promote cancer clinical trial accrual remains unknown. Future efforts are needed to explore whether Twitter can emerge as a viable medium for clinical trial recruitment.