In PharmacoEconomics, Sean Murphy and Daniel Polsky review the literature on economic evaluations of opioid use disorder interventions. Evidence of effectiveness does not always lead to adoption of a given therapy. Economic evaluations can provide evidence that will help stakeholders efficiently allocate their resources. Murphy and Polsky conducted a systemic review of major electronic databases from inception until 2015. Forty-nine studies were included in the study. They find that the economic literature on methadone maintenance therapy (MMT) supports previous findings that MMT is an economically advantageous opioid use disorder therapy. The economic literature comparing MMT with other opioid use disorder pharmacotherapies is limited, as is the literature on other forms of therapy. Additional economic evaluations are needed to assess the relative value of existing opioid use disorder interventions.