Effectiveness of Androgen-Deprivation Therapy and Radiotherapy for Older Men With Locally Advanced Prostate Cancer

In the Journal of Clinical Oncology, Justin Bekelman and colleagues analyze whether treating locally advanced prostate cancer in older men with hormone therapy plus radiation improves chances of survival relative to hormone therapy alone. Earlier trials have shown that the combined course of treatment improves chances of survival for younger men. Bekelman and colleagues’ study tests whether this holds true for the treatment of older men with advanced prostate cancer. The authors compared the treatment of 31,541 men with prostate cancer ranging in age from 65 years to 85 years. Among men age 65 to 75 years old, radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 57 percent relative to hormone therapy alone (from 9.8 percent to 4.4 percent of patients at 7 years follow up). Similarly, among men age 76 to 85 years old, radiation plus hormone therapy was associated with a reduction in prostate cancer deaths of 49 percent relative to hormone therapy alone (from 9.8 percent to 5.0 percent of patients at 7 years follow-up). In both groups, radiation plus hormone therapy was also associated with about one-third fewer deaths from any cause.