Medication Adherence

Whether and why patients take their medications as prescribed, for as long as prescribed, and the factors that encourage greater compliance with drug regimens.

The Habit Formation trial of behavioral economic interventions to improve statin use and reduce the risk of cardiovascular disease: Rationale, design and methodologies

Aug. 16, 2019

Peter P ReeseKevin G VolppLouise B Russell, George Loewenstein, Jiali Yan, David Pagnotti, Ryan McGilloway, Troyen Brennen, Darra Finnerty, Karen Hoffer, Sakshum Chadha, Iwan Barankay

Abstract [from journal]

Background: Low adherence to statin (HMG-CoA reductase inhibitors) medication is common. Here, we report on the design and implementation of the Habit Formation trial. This clinical trial assessed whether the interventions, based on principles from behavioral economics, might improve statin adherence and lipid control in at-risk populations. We describe the rationale and methods for the trial, recruitment, conduct and follow-up. We also report on several barriers we encountered


Electronic Pill Bottles or Bidirectional Text Messaging to Improve Hypertension Medication Adherence (Way 2 Text): a Randomized Clinical Trial

Shivan J. Mehta, MD, MBA
Aug. 8, 2019

Shivan J. Mehta, Kevin G. Volpp, Andrea B. Troxel, Susan C. Day, Raymond Lim, Noora Marcus, Laurie Norton, Sophia Anderson, David A. Asch

Abstract [from journal]

Background: Poor medication adherence contributes to inadequate control of hypertension. However, the value of adherence monitoring is unknown.

Objective: To evaluate the impact of monitoring adherence with electronic pill bottles or bidirectional text messaging on improving hypertension control.

Design: Three-arm pragmatic randomized controlled trial.

Patients: One hundred forty-nine primary care patients aged 18-75 with hypertension and text messaging capabilities who


Tailored medication adherence incentives for high-risk children with asthma: a pilot study

Chen Kenyon, MD, MSHP
Aug. 7, 2019

Chén C. Kenyon, Kavya G. Sundar, Siobhan M. Gruschow, William O. Quarshie, Chris Feudtner, Tyra C. Bryant-Stephens, Victoria A. Miller

Abstract [from journal]

Objective: While reminder-based electronic monitoring systems have shown promise in enhancing inhaled corticosteroid (ICS) adherence in select populations, more engaging strategies may be needed in families of children with high-risk asthma. This study assesses the acceptability and feasibility of gain-framed ICS adherence incentives in families of urban, minority children with frequent asthma hospitalization. 

Methods: We enrolled children aged 5-11 years with multiple yearly asthma hospitalizations in a 2-


Factors Associated with Potentially Inappropriate Medication Use in Community‐Dwelling Older Adults in the United States: A Systematic Review

Apr. 9, 2019

Stephanie K. Nothelle, Ritu Sharma, Allison Oakes, Madeline Jackson, Jodi B. Segal

Abstract [from journal]

Objectives: Potentially inappropriate medication (PIM) use in older adults is a prevalent problem associated with poor health outcomes. Understanding drivers of PIM use is essential for targeting interventions. This study systematically reviews the literature about the patient, clinician and environmental/system factors associated with PIM use in community‐dwelling older adults in the United States.


Inside the Black Box of Patient-Centered Medical Homes

Aug. 2, 2018

The concept of a patient-centered medical home (PCMH) holds intuitive appeal, with its emphasis on coordination of care, improved patient-provider communication and patient engagement, use of health information technology, and expanded practice hours.

Trends in P2Y12 Receptor Inhibitor Use and Adherence After Percutaneous Coronary Intervention, 2008-2016

Research Brief
May. 25, 2018

Post-angioplasty, patient adherence to recommended antiplatelet therapy decreased when newer, more expensive drugs were introduced. From 2008-2016, as the use of newer agents increased, the proportion of patients not filling any antiplatelet prescription within 30 days of discharge increased from 6.4% to 19.1%. In the subsequent 12 months, the newer drugs were associated with higher patient costs and lower adherence to recommended therapy.