Wade Berrettini, MD, PhD


Karl E. Rickels Professor, Psychiatry, Perelman School of Medicine

Dr. Berrettini is the Karl E. Rickels Professor of Psychiatry, at the University of Pennsylvania Perelman School of Medicine. He earned his MD degree (1977) and PhD degree (Pharmacology, 1979) from Thomas Jefferson University. After psychiatry residency training, he studied genetics of behavioral disorders at the Intramural Research Program of the National Institute of Mental Health for ten years. Since 1997 Dr. Berrettini has served as the Director of the Center for Neurobiology and Behavior, a group of interdisciplinary scientists studying genetic and biologic influences on brain disorders. The author of ~400 peer-reviewed publications, his research interests include genetics, pharmacogenetics and medical treatment of addictions, mood disorders, schizophrenia and epilepsy. The Berrettini lab is currently studying somatic mutation in neurons as potential causative factors in risk for addictions, psychotic illnesses and epilepsy. Another focus of the lab is the study of a novel compound as a therapeutic agent in cocaine addiction. Lastly, Dr. Berrettini is studying clinical and genetic predictors of risk for opioid addiction among patients treated chronically with opioids for non-progressive musculo-skeletal pain.

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