Illustrations are adapted from the JAMA Viewpoint Figure. The area between the two vertical dotted lines indicates the period in which NIH funding doubled.
In a recent JAMA Viewpoint, Penn LDI Senior Fellow Nadir Yehya notes that between 1998 and 2003, the NIH budget doubled in nominal terms—the actual dollar amounts spent or allocated each year, not adjusted for inflation. This period was marked by robust bipartisan investment in biomedical research. But that rapid growth proved short-lived. Since peaking in 2003, the NIH budget has stagnated or declined in real dollars, meaning figures adjusted for inflation using the Consumer Price Index (CPI), even as the U.S. population grew by nearly 50 million and research costs rose sharply.
By 2024, the NIH budget in real terms stood about 7.4% lower than its 2003 peak, underscoring a sustained failure to keep pace with inflation and the rising cost of scientific research. As policymakers weigh potential cuts, this inflation-adjusted trajectory is a critical data point for setting funding priorities that reflect the long-term needs of the biomedical research enterprise.
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