Zachary Meisel

Zachary F. Meisel, MD, MPH, MSHP

Associate Professor, Emergency Medicine, Perelman School of Medicine

Zachary F. Meisel, MD, MPH, MSHP is Associate Professor of Emergency Medicine and Director of the Center for Emergency Care Policy and Research and at the Perelman School of Medicine at the University of Pennsylvania. He serves as the Patient Safety Officer at the Hospital of the University of Pennsylvania, the primary hospital of Penn Medicine. Dr. Meisel’s research interests include pain treatment and opioid prescriptions, narrative communication, guideline adherence, opioid use disorder, patient safety, emergency medical services, and patient centered comparative effectiveness research. He has a specific focus on using and testing persuasive narratives to promote evidence translation to patients, providers and policy makers. Dr. Meisel studies ways to improve the translation of research evidence, particularly around prescription opioids.

He is the principal investigator of the Life STORRIED study (Life Stories for Opioid Risk Reduction in the Emergency Department) a multi-year, multi-center Patient Centered Outcomes Research Institute (PCORI) funded clinical trial focusing on the comparative effectiveness of probabilistic versus patient narrative enhanced risk communication for pain management following emergency care. He also directs the Policy and Dissemination core for the NIDA-funded Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV ( He has served as principal investigator or co-PI of major grants from Agency for Healthcare Research and Quality (AHRQ) and the WT Grant Foundation, focused on the translation of evidence to providers and patients. He is also member of the executive committee for the Penn Injury Science Center (PISC).

Dr. Meisel is also a medical columnist for Slate and Time with expertise in dissemination translation of health services research results for audiences such as patients and policy makers. He is Senior Associate Editor for Health Communication for the journal Academic Emergency Medicine. He served on the Philadelphia Mayor’s Task Force to Combat the Opioid Epidemic in 2017.